SCHEMBL20172269

SCHEMBL20172269

Nc1cccc2sc3cnccc3c12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.49
CYP2D6 P10635 2/20 0.49
CYP2C9 P11712 2/20 0.49
CYP2C19 P33261 2/20 0.49
LMNA P02545 1/20 0.49
CYP1A2 P05177 1/20 0.49
KDM4E B2RXH2 3/20 0.40
HTT P42858 2/20 0.40
GAA P10253 2/20 0.40
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
HSD17B10 Q99714 2/20 0.40
GLA P06280 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
NCOA1 Q15788 1/20 0.40
RCE1 Q9Y256 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
AXL P30530 1/20 0.36
EP300 Q09472 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20172154 0.86 CYP3A4 (0.44) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL22373798 0.81 ALDH1A1 (0.38) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL16693487 0.79 MAPK1 (0.39) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL3292566 0.77 GPR3 (0.54) CYP3A4CYP2C9CYP2C19LMNACYP1A2
SCHEMBL29671007 0.77 GPR3 (0.54) CYP3A4CYP2C9CYP2C19LMNACYP1A2
SCHEMBL20172397 0.76 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL21237832 0.76 HPGD (0.35) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL17472496 0.76 KDM4E (0.38) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL3875482 0.74 ALDH1A1 (0.41) CYP3A4LMNAKDM4EGAAALDH1A1
SCHEMBL11885002 0.74 KDM4E (0.44) CYP3A4CYP2D6CYP2C9CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3339395-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2019-10-02 EP disclosed
EP-3339395-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME Samsung Electronics Co., Ltd. (KR) 2018-06-27 EP disclosed
EP-2980182-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2018-05-23 EP disclosed