SCHEMBL20172154

SCHEMBL20172154

Nc1cccc2sc3ccncc3c12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
LMNA P02545 1/20 0.44
CYP1A2 P05177 1/20 0.44
KDM4E B2RXH2 1/20 0.38
POLB P06746 1/20 0.38
HTT P42858 1/20 0.38
RAD52 P43351 1/20 0.38
AXL P30530 1/20 0.36
EP300 Q09472 1/20 0.36
KAT2B Q92831 1/20 0.36
KAT8 Q9H7Z6 1/20 0.36
CYP2A6 P11509 3/20 0.35
GPR3 P46089 1/20 0.34
RAB9A P51151 2/20 0.33
MAPT P10636 2/20 0.33
EGFR P00533 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20172269 0.86 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL22373860 0.81 ALDH1A1 (0.36) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL24055843 0.79 MAPK1 (0.39) LMNAGPR3RAB9AMAPTEGFR
SCHEMBL20172173 0.79 GPR3 (0.34) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL3292566 0.77 GPR3 (0.54) CYP3A4CYP2C9CYP2C19LMNACYP1A2
SCHEMBL29671007 0.77 GPR3 (0.54) CYP3A4CYP2C9CYP2C19LMNACYP1A2
SCHEMBL17489630 0.76 CYP3A4 (0.44) CYP3A4CYP2D6CYP2C9CYP2C19LMNA
SCHEMBL21237831 0.76 SLC9A1 (0.35) CYP3A4CYP2D6LMNACYP1A2GPR3
SCHEMBL3875482 0.74 ALDH1A1 (0.41) CYP3A4LMNAKDM4EAXLGPR3
SCHEMBL11884982 0.74 CYP2A6 (0.42) AXLEP300KAT2BKAT8CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3339395-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2019-10-02 EP disclosed
EP-3339395-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME Samsung Electronics Co., Ltd. (KR) 2018-06-27 EP disclosed
EP-2980182-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2018-05-23 EP disclosed