Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | SCNN1A | P37088 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016915 | 0.94 | MAPT (0.46) | MAPTNPC1NLRP3PPARGNPSR1 | |
| SCHEMBL12635938 | 0.87 | MAPT (0.46) | MAPTNPC1NLRP3NPSR1CYP1A2 | |
| SCHEMBL2014103 | 0.86 | SCNN1A (0.43) | MAPTNPC1NLRP3PPARGSCNN1A | |
| SCHEMBL12635760 | 0.82 | SCNN1A (0.38) | MAPTNPC1NLRP3PPARGSCNN1A | |
| SCHEMBL2014866 | 0.81 | SMN1; SMN2 (0.52) | MAPTNPC1CYP1A2CYP3A4CYP2D6 | |
| Iodide SCHEMBL2016181 | 0.81 | SCNN1A (0.38) | MAPTNPC1NLRP3PPARGSCNN1A | |
| SCHEMBL12636304 | 0.80 | SCNN1A (0.38) | MAPTNPC1NLRP3SCNN1A | |
| Iodide SCHEMBL2018286 | 0.80 | SCNN1A (0.38) | MAPTNPC1NLRP3SCNN1A | |
| SCHEMBL12635742 | 0.79 | CHEK2 (0.41) | MAPTNPC1NLRP3PPARGNPSR1 | |
| SCHEMBL2017964 | 0.79 | SCNN1A (0.44) | MAPTNPC1NLRP3PPARGCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |