Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014103 | 0.94 | SCNN1A (0.43) | SCNN1APPARGHTTMAPTTP53 | |
| SCHEMBL2018438 | 0.94 | SCNN1A (0.44) | SCNN1AHTTMAPTTP53SMN1; SMN2 | |
| SCHEMBL2015344 | 0.90 | HTT (0.47) | PPARGHTTMAPTTP53SMN1; SMN2 | |
| SCHEMBL2016536 | 0.87 | HTT (0.42) | SCNN1AHTTCTSAACSS2 | |
| SCHEMBL12635952 | 0.86 | HTT (0.41) | SCNN1AHTTMAPTTP53SMN1; SMN2 | |
| SCHEMBL12635701 | 0.86 | ACSS2 (0.49) | SCNN1AHTTS1PR1ACSS2 | |
| SCHEMBL2040435 | 0.86 | HTT (0.45) | HTTMAPTTP53SMN1; SMN2CTSA | |
| SCHEMBL2018430 | 0.86 | ACSS2 (0.42) | SCNN1AHTTACSS2 | |
| SCHEMBL2020165 | 0.85 | ACSS2 (0.46) | SCNN1AHTTACSS2 | |
| SCHEMBL2016915 | 0.85 | MAPT (0.46) | SCNN1APPARGMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |