Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017964 | 0.94 | SCNN1A (0.44) | SCNN1APPARGMAPTNPC1NLRP3 | |
| SCHEMBL2018438 | 0.87 | SCNN1A (0.44) | SCNN1AMAPTHTTSMN1; SMN2TP53 | |
| SCHEMBL2017353 | 0.86 | MAPT (0.52) | SCNN1APPARGMAPTNPC1NLRP3 | |
| SCHEMBL2018490 | 0.85 | KDM4E (0.53) | SCNN1AMAPTNPC1NLRP3HTT | |
| SCHEMBL2015344 | 0.84 | HTT (0.47) | PPARGMAPTHTTSMN1; SMN2TP53 | |
| SCHEMBL2019895 | 0.83 | HTT (0.44) | PPARGHTTTP53CTSAHDAC6 | |
| SCHEMBL2019532 | 0.83 | HDAC6 (0.49) | SCNN1APPARGMAPTHTTKDM4E | |
| Iodide SCHEMBL2019374 | 0.83 | HTT (0.43) | PPARGHTTTP53CTSAHDAC6 | |
| SCHEMBL12635745 | 0.82 | SCNN1A (0.42) | SCNN1AMAPTSMN1; SMN2TP53CTSA | |
| SCHEMBL2014471 | 0.81 | MAPT (0.52) | MAPTNPC1NLRP3HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |