Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | MAP2K3 | P46734 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.42 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30223610 | 0.85 | KDM4E (0.47) | LMNAKDM4EADORA3PKMADORA2A | |
| SCHEMBL3254262 | 0.80 | KDM4E (0.44) | LMNAKDM4EADORA3PKMADORA2A | |
| SCHEMBL13440420 | 0.79 | MEN1 (0.49) | LMNAKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL15090938 | 0.77 | HSD17B10 (0.50) | LMNAKDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL1840712 | 0.76 | ALDH1A1 (0.49) | LMNAKDM4EADORA3PKMADORA2A | |
| SCHEMBL26606779 | 0.76 | THRB (0.46) | LMNAKDM4EADORA3PKMADORA2A | |
| SCHEMBL11259275 | 0.75 | KDR (0.46) | CYP1A2IKBKB | |
| SCHEMBL30471260 | 0.73 | LCK (0.67) | LMNAKDM4EADORA3PKMADORA2A | |
| Formamide SCHEMBL28891685 | 0.71 | ALDH1A1 (0.44) | KDM4EHSD17B10ALDH1A1CYP1A2HPGD | |
| SCHEMBL11940152 | 0.71 | KDM4E (0.39) | LMNAKDM4EADORA3PKMADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |