Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011676 | 0.85 | KDM4E (0.41) | ADORA2ALMNAHPGDGABRPGABRD | |
| SCHEMBL2012012 | 0.75 | PIN1 (0.49) | ADORA2APTGDR2 | |
| SCHEMBL2163437 | 0.74 | TRPM8 (0.44) | ADORA2ATRPM8PTGDR2CYP1A2 | |
| SCHEMBL2015782 | 0.71 | NT5E (0.36) | ADORA2ALMNAHPGDGABRPGABRD | |
| SCHEMBL2013193 | 0.71 | ADORA2A (0.41) | ADORA2AMAT2AGCGRTRPM8 | |
| SCHEMBL2016547 | 0.71 | SMN1; SMN2 (0.45) | LMNAHPGDTRPM8 | |
| SCHEMBL2012708 | 0.71 | CCR1 (0.39) | ADORA2AARTNKS2TGFBR1 | |
| SCHEMBL12125684 | 0.70 | TAAR1 (0.48) | ADORA2ALMNAHPGDGABRPGABRD | |
| SCHEMBL3907818 | 0.70 | AR (0.41) | ARTNKS2HCRTR1 | |
| SCHEMBL2015837 | 0.68 | KDM4E (0.38) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |