Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.62 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16254296 | 1.00 | MMP8 (0.62) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL18435192 | 0.86 | MMP8 (0.60) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL16252288 | 0.86 | MMP8 (0.60) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL16254311 | 0.86 | FPR2 (0.59) | MMP1MMP3ALDH1A1TSHRHRH2 | |
| SCHEMBL7325333 | 0.84 | MMP8 (0.57) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL7317525 | 0.84 | MMP8 (0.57) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL7317522 | 0.84 | MMP8 (0.57) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL7319235 | 0.82 | MMP8 (0.55) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL7389781 | 0.82 | MMP8 (0.55) | MMP8MMP1MMP3ALDH1A1TSHR | |
| SCHEMBL23879139 | 0.81 | MEN1 (0.56) | MMP8MMP1MMP3ALDH1A1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141947-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141947-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | PIK3CD, PIK3CA, PI4KA | MMP8 1832/4885MMP1 1721/4885MMP3 2375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.