Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | REN | P00797 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317525 | 1.00 | MMP8 (0.57) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL7325333 | 1.00 | MMP8 (0.57) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL7389781 | 0.90 | MMP8 (0.55) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL7319235 | 0.90 | MMP8 (0.55) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL18435192 | 0.90 | MMP8 (0.60) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL16252288 | 0.90 | MMP8 (0.60) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL20176845 | 0.84 | MMP8 (0.62) | MMP8TSHRMMP1MMP3ALDH1A1 | |
| SCHEMBL16254296 | 0.84 | MMP8 (0.62) | MMP8TSHRMMP1MMP3ALDH1A1 | |
| SCHEMBL7389855 | 0.82 | REN (0.54) | MMP8RENTSHRMMP1MMP3 | |
| SCHEMBL22415331 | 0.80 | HSD17B10 (0.71) | MMP8TSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |