Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168404 | 0.83 | NOTUM (0.43) | NOTUMGABRA2GABRB2KDM4EALDH1A1 | |
| SCHEMBL21265982 | 0.82 | NOTUM (0.42) | NOTUMGABRA2GABRB2KDM4EALDH1A1 | |
| SCHEMBL14151307 | 0.79 | NOTUM (0.48) | NOTUMGABRA2GABRB2KDM4EALDH1A1 | |
| SCHEMBL25153647 | 0.77 | NOTUM (0.51) | NOTUMGABRA2GABRB2KDM4EALDH1A1 | |
| SCHEMBL24757824 | 0.75 | DGAT1 (0.37) | NOTUMGABRA2GABRB2ALDH1A1LMNA | |
| SCHEMBL20177079 | 0.75 | GABRA2 (0.41) | GABRA2GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL28934829 | 0.75 | NOTUM (0.49) | NOTUMGABRA2GABRB2KDM4EALDH1A1 | |
| SCHEMBL12458917 | 0.74 | KMT2A (0.42) | NOTUM | |
| SCHEMBL24036185 | 0.74 | NOTUM (0.48) | NOTUMGABRA2GABRB2KDM4EALDH1A1 | |
| SCHEMBL20857112 | 0.72 | NOTUM (0.47) | NOTUMGABRA2GABRB2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535258-B1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-24 | — | — | EP | disclosed |
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |