Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.42 |
| ▸ | CPB1 | P15086 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30268850 | 0.89 | CNR2 (0.46) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL24036185 | 0.89 | NOTUM (0.48) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL29065096 | 0.88 | NOTUM (0.47) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL20857112 | 0.88 | NOTUM (0.47) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL25153647 | 0.87 | NOTUM (0.51) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL2282033 | 0.85 | CPB2 (0.45) | KDM5AKDM5BCPB2CPB1MEN1 | |
| SCHEMBL22859643 | 0.85 | NOTUM (0.45) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL20868509 | 0.85 | NOTUM (0.45) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL30893298 | 0.85 | NOTUM (0.45) | NOTUMCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL14151307 | 0.83 | NOTUM (0.48) | NOTUMCYP1A2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461338-B | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2024-02-20 | — | — | CN | disclosed |
| CN-115461338-A | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2022-12-09 | — | — | CN | disclosed |