Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | P4HB | P07237 | 8/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22359857 | 0.76 | GSK3B (0.46) | GSK3BENPP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8383017 | 0.75 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPT | |
| SCHEMBL30601284 | 0.74 | FBP1 (0.51) | P4HBENPP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL471486 | 0.74 | FBP1 (0.51) | P4HBENPP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10243324 | 0.73 | CLK4 (0.47) | CLK4 | |
| SCHEMBL16502093 | 0.72 | GSK3B (0.53) | GSK3BP4HBENPP2ADORA2ACLK4 | |
| Ethane SCHEMBL28057226 | 0.72 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPT | |
| SCHEMBL14508038 | 0.71 | GSK3B (0.51) | GSK3BP4HBENPP2CLK4FBP1 | |
| SCHEMBL3348656 | 0.71 | GSK3B (0.51) | GSK3BP4HBENPP2CLK4GRM5 | |
| SCHEMBL28080869 | 0.71 | GSK3B (0.51) | GSK3BP4HBENPP2CLK4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093696-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |