Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 19/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177769 | 0.91 | APLNR (0.47) | APLNRMAPT | |
| SCHEMBL20177791 | 0.91 | APLNR (0.39) | APLNRMAPTHPGDGFER | |
| SCHEMBL20177615 | 0.86 | APLNR (0.44) | APLNRMAPTHPGDGFER | |
| SCHEMBL20177618 | 0.83 | APLNR (0.71) | APLNR | |
| SCHEMBL20177593 | 0.83 | APLNR (0.46) | APLNRMAPTHPGDGFER | |
| SCHEMBL20177966 | 0.81 | ALDH1A1 (0.40) | APLNRMAPTHPGD | |
| SCHEMBL20168388 | 0.81 | APLNR (0.60) | APLNR | |
| SCHEMBL20200844 | 0.79 | APLNR (0.62) | APLNR | |
| SCHEMBL20166129 | 0.76 | APLNR (0.80) | APLNR | |
| SCHEMBL22537345 | 0.76 | APLNR (0.44) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093577-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |