Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 9/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177769 | 0.91 | APLNR (0.47) | ALDH1A1GAAKDM4EGLAMAPT | |
| SCHEMBL20177791 | 0.90 | APLNR (0.39) | ALDH1A1GAAKDM4EGLAMAPT | |
| SCHEMBL20177619 | 0.81 | APLNR (0.49) | MAPTAPLNRHPGD | |
| SCHEMBL20167355 | 0.78 | APLNR (0.60) | APLNR | |
| SCHEMBL20168388 | 0.72 | APLNR (0.60) | APLNR | |
| SCHEMBL20177615 | 0.69 | APLNR (0.44) | ALDH1A1MAPTAPLNRHPGDTSHR | |
| SCHEMBL20177593 | 0.68 | APLNR (0.46) | MAPTAPLNRHPGD | |
| SCHEMBL20177731 | 0.68 | ALDH1A1 (0.35) | ALDH1A1RAB9ANPSR1MEN1KMT2A | |
| SCHEMBL20166129 | 0.64 | APLNR (0.80) | APLNR | |
| SCHEMBL20177578 | 0.59 | APLNR (0.44) | ALDH1A1KDM4EAPLNRHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093577-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |