Sialic Acid

Sialic Acid

SCHEMBL2017776

CC(=O)N[C@@H]1[C@@H]([C@@H](O)[C@@H](O)CO)O[C@](O)(C(=O)O)C[C@H]1O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NANP Q8TBE9 3/20 0.72
L3MBTL1 Q9Y468 1/20 0.68
NEU2 Q9Y3R4 3/20 0.47
NEU4 Q8WWR8 2/20 0.47
NEU3 Q9UQ49 2/20 0.47
NEU1 Q99519 1/20 0.47
SELL P14151 1/20 0.43
SELP P16109 1/20 0.43
MAG P20916 2/20 0.42
SIGLEC7 Q9Y286 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sialic Acid SCHEMBL22412 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL12391269 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22879166 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL20299824 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL23366253 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL804644 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL24274184 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22279106 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL21067569 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22943658 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11813295-B1 Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity Theobald Therapeutics LLC (US) 2023-11-14 US claimed
US-20210401863-A1 TREATMENT AND PREVENTION OF NEISSERIA GONORRHOEAE INFECTION USING CMP-ACTIVATED NONULOSONATE ANALOG COMPOUNDS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2021-12-30 US claimed
WO-1999029705-A9 SIALYL LEWIS X AND SIALYL LEWIS A GLYCOMIMETICS GLYCOMED INC (US) 1999-11-11 WO claimed
US-12582612-B2 Pharmaceutical composition of Siglec-binding agents CYTODIGM, INC. (US) 2026-03-24 US disclosed
EP-3962491-B1 INTRACELLULAR DELIVERY OF ANTI-KRAS ANTIBODIES FORMULATED INTO NANOCAPSULES UNIV SANTIAGO COMPOSTELA (ES) 2025-08-06 EP disclosed
CN-119950526-A Compound preparation containing N-acetylneuraminic acid ester derivatives and preparation method and application thereof 铭畅生物医药南通有限公司 2025-05-09 CN disclosed
EP-4351520-A1 NOVEL PARTICLE COMPOSITION COMPRISING SIALIC ACID BINDING LIGAND CYTODIGM, INC. (US) 2024-04-17 EP disclosed
CN-117750946-A Novel particulate compositions comprising sialic acid binding ligands 希托迪格姆公司 2024-03-22 CN disclosed
CN-115420821-B Click-iG: identification method of multiple types of complete glycopeptides 北京大学 2024-03-01 CN disclosed
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
EP-4225278-A1 PHARMACEUTICAL COMPOSITION OF SIGLEC-BINDING AGENTS CYTODIGM, INC. (US) 2023-08-16 EP disclosed
EP-1654289-B1 POLYSIALIC ACID DERIVATIVES LIPOXEN TECHNOLOGIES LTD (GB) 2007-10-03 EP disclosed
CN-101031655-A Method for improving protein expression by strain engineering DOW GLOBAL TECHNOLOGIES INC (US) 2007-09-05 CN disclosed
US-20060270830-A1 Polysialic acid derivatives OPKO PHARMACEUTICALS, LLC 2006-11-30 US disclosed
EP-1654289-A1 POLYSIALIC ACID DERIVATIVES Lipoxen Technologies Limited (GB) 2006-05-10 EP disclosed
WO-2005016973-A1 POLYSIALIC ACID DERIVATIVES LIPOXEN TECHNOLOGIES LIMITED (GB) 2005-02-24 WO disclosed
CN-1359426-A neisseria genomic sequences and methods of use thereof CHIRON CORP (US) 2002-07-17 CN disclosed
EP-0587639-B1 PHARMACEUTICAL COMPOSITIONS LIPOXEN LTD (GB) 2001-08-16 EP disclosed
WO-1999029705-A9 SIALYL LEWIS X AND SIALYL LEWIS A GLYCOMIMETICS GLYCOMED INC (US) 1999-11-11 WO disclosed
US-5846951-A Pharmaceutical compositions THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) 1998-12-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060270830-A1 Polysialic acid derivatives MPST, SUMO2, SUMO1 NANP 456/4885L3MBTL1 3313/4885NEU2 19/4885
US-20210401863-A1 TREATMENT AND PREVENTION OF NEISSERIA GONORRHOEAE INFECTION USING CMP-ACTIVATED NONULOSONATE ANALOG COMPOUNDS ST3GAL3, B3GNT2, FUT5 NANP 48/4885L3MBTL1 4790/4885NEU2 71/4885
US-12582612-B2 Pharmaceutical composition of Siglec-binding agents SIGLEC7, SIGLEC9, CD2 NANP 221/4885L3MBTL1 4101/4885NEU2 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.