Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 14/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.31 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.31 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.31 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.31 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.31 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766929 | 1.00 | APLNR (0.51) | APLNRSIRT6CA1CA2NNMT | |
| SCHEMBL18246990 | 0.81 | APLNR (0.42) | APLNRSIRT6TSHR | |
| SCHEMBL20177980 | 0.79 | APLNR (0.38) | APLNR | |
| SCHEMBL30665043 | 0.78 | SIRT6 (0.43) | APLNRSIRT6NNMTTUBB4ATUBB | |
| SCHEMBL22332822 | 0.74 | SIRT6 (0.45) | APLNRSIRT6CA1CA2NNMT | |
| SCHEMBL28452726 | 0.74 | APLNR (0.43) | APLNRCA1CA2 | |
| SCHEMBL19574019 | 0.71 | LMNA (0.43) | APLNRCA1CA2 | |
| SCHEMBL17541055 | 0.70 | SIRT6 (0.50) | APLNRSIRT6NNMTTSHRTUBB4A | |
| SCHEMBL21767155 | 0.70 | APLNR (0.39) | APLNRCA2 | |
| SCHEMBL18504964 | 0.70 | APLNR (0.50) | APLNRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-B9 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |