Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12852534 | 0.84 | MAOA (0.52) | NOTUMALDH1A1MAOAMAOBDRD2 | |
| SCHEMBL12363775 | 0.84 | MAOA (0.52) | NOTUMKDM4EALDH1A1POLBMAOA | |
| SCHEMBL20119243 | 0.83 | MAOA (0.39) | ALDH1A1MAOAMAOBDRD2HTR2A | |
| SCHEMBL20119408 | 0.79 | ACACB (0.40) | NOTUMTEAD1TEAD4TEAD2DRD2 | |
| SCHEMBL21882783 | 0.78 | DRD2 (0.42) | NOTUMTEAD1TEAD4TEAD2KDM4E | |
| SCHEMBL20178629 | 0.76 | NOTUM (0.32) | NOTUMKDM4EALDH1A1POLBHTR2A | |
| SCHEMBL21882589 | 0.75 | ACACB (0.38) | NOTUMTEAD1TEAD4TEAD2DRD2 | |
| SCHEMBL7898062 | 0.75 | KCNH2 (0.44) | NOTUMMAOAMAOBDRD2TIPARP | |
| SCHEMBL21882591 | 0.73 | CYP1A2 (0.34) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL21882595 | 0.73 | KCNH2 (0.44) | NOTUMTEAD1TEAD4TEAD2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | NOTUM 1474/4885TEAD1 1669/4885TEAD4 1572/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | NOTUM 1474/4885TEAD1 1669/4885TEAD4 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.