Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178641 | 0.87 | ALDH1A1 (0.51) | NAMPTALDH1A1POLBHDAC6HDAC8 | |
| SCHEMBL10120336 | 0.82 | HDAC6 (0.62) | NAMPTL3MBTL3L3MBTL1HDAC6HDAC8 | |
| SCHEMBL20178659 | 0.82 | NAMPT (0.56) | NAMPTL3MBTL3ALDH1A1SRD5A2SRD5A1 | |
| SCHEMBL19719191 | 0.81 | L3MBTL3 (0.54) | NAMPTL3MBTL3L3MBTL1HDAC6HDAC8 | |
| SCHEMBL3313453 | 0.80 | ALDH1A1 (0.53) | NAMPTALDH1A1POLBSRD5A2SRD5A1 | |
| SCHEMBL8122252 | 0.79 | HDAC1 (0.55) | KDM1ASRD5A2L3MBTL1HCAR3HDAC6 | |
| SCHEMBL3604547 | 0.79 | ALDH1A1 (0.49) | NAMPTALDH1A1HCAR3KMT2A | |
| Hydrochloric Acid SCHEMBL7040966 | 0.78 | HDAC1 (0.54) | KDM1ASRD5A2L3MBTL1HCAR3HDAC6 | |
| Hydrochloric Acid SCHEMBL7041877 | 0.78 | HDAC1 (0.54) | KDM1ASRD5A2L3MBTL1HCAR3HDAC6 | |
| SCHEMBL7277193 | 0.77 | NOTUM (0.58) | NAMPTALDH1A1POLBSRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | NAMPT 1633/4885L3MBTL3 4813/4885ALDH1A1 2185/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | NAMPT 1633/4885L3MBTL3 4813/4885ALDH1A1 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.