Sugi Predict

Sugi Predict / Compounds / SCHEMBL20179240

SCHEMBL20179240

SCHEMBL20179240

CC(C)(C)OC(=O)c1cccc(CC(CCC(=O)NO)C(=O)OC(C)(C)C)c1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 2/20 0.55
▸ FOLH1 Q04609 9/20 0.47
▸ MEP1B Q16820 1/20 0.42
▸ LOXL2 Q9Y4K0 1/20 0.38
▸ LTA4H P09960 1/20 0.37
▸ CYP4F2 P78329 1/20 0.37
▸ CYP4A11 Q02928 1/20 0.37
▸ HDAC3 O15379 1/20 0.37
▸ HDAC4 P56524 1/20 0.37
▸ HDAC1 Q13547 1/20 0.37
▸ HDAC7 Q8WUI4 1/20 0.37
▸ HDAC2 Q92769 1/20 0.37
▸ HDAC10 Q969S8 1/20 0.37
▸ HDAC11 Q96DB2 1/20 0.37
▸ HDAC8 Q9BY41 1/20 0.37
▸ HDAC6 Q9UBN7 1/20 0.37
▸ HDAC9 Q9UKV0 1/20 0.37
▸ HDAC5 Q9UQL6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20168300 0.91 FOLH1 (0.57) SLC7A5FOLH1MEP1B
SCHEMBL20168326 0.90 SLC7A5 (0.61) SLC7A5FOLH1MEP1BLOXL2
SCHEMBL20179143 0.87 SLC7A5 (0.56) SLC7A5FOLH1LOXL2LTA4HCYP4F2
SCHEMBL20179149 0.86 SLC7A5 (0.53) SLC7A5FOLH1LOXL2LTA4H
SCHEMBL20179198 0.86 SLC7A5 (0.55) SLC7A5FOLH1LOXL2LTA4H
SCHEMBL20179348 0.86 SLC7A5 (0.53) SLC7A5FOLH1LOXL2LTA4HCYP4F2
SCHEMBL21578048 0.86 SLC7A5 (0.57) SLC7A5FOLH1MEP1BLOXL2CYP4F2
SCHEMBL20179137 0.86 FOLH1 (0.54) SLC7A5FOLH1HDAC3HDAC4HDAC1
SCHEMBL20179232 0.86 SLC7A5 (0.52) SLC7A5FOLH1MEP1BLOXL2LTA4H
SCHEMBL20179153 0.85 SLC7A5 (0.51) SLC7A5FOLH1MEP1BLOXL2LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866394-B2 Prodrugs of hydroxamate-based GCPII inhibitors THE JOHNS HOPKINS UNIVERSTY (US) 2024-01-09 — — US disclosed
US-20210355079-A1 PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I. (CZ) 2021-11-18 — — US disclosed
US-11059775-B2 Prodrug compositions and utility of hydroxamate-based GCPII inhibitors THE JOHNS HOPKINS UNIVERSITY (US) 2021-07-13 — — US disclosed
US-20190352255-A1 NOVEL PRODRUG COMPOSITIONS AND UTILITY OF HYDROXAMATE-BASED GCPII INHIBITORS THE JOHNS HOPKINS UNIVERSITY 2019-11-21 — — US disclosed
WO-2018094334-A1 PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS THE JOHNS HOPKINS UNIVERSITY (US) 2018-05-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190352255-A1 NOVEL PRODRUG COMPOSITIONS AND UTILITY OF HYDROXAMATE-BASED GCPII INHIBITORS GPI, TPI1, HPGDS SLC7A5 505/4885FOLH1 10/4885MEP1B 1571/4885
US-20210355079-A1 PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS TPI1, HPGDS, GPI SLC7A5 463/4885FOLH1 39/4885MEP1B 2006/4885
US-11059775-B2 Prodrug compositions and utility of hydroxamate-based GCPII inhibitors GLS, HPGDS, GPI SLC7A5 536/4885FOLH1 15/4885MEP1B 1555/4885
US-11866394-B2 Prodrugs of hydroxamate-based GCPII inhibitors TPI1, HPGDS, GPI SLC7A5 463/4885FOLH1 39/4885MEP1B 2006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.