Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796155 | 0.80 | LMNA (0.42) | CTSL | |
| SCHEMBL28343640 | 0.79 | AOC3 (0.43) | — | |
| SCHEMBL28343639 | 0.79 | AOC3 (0.43) | — | |
| SCHEMBL765398 | 0.78 | PABPC1 (0.52) | CTSK | |
| SCHEMBL20179578 | 0.78 | PABPC1 (0.52) | CTSK | |
| SCHEMBL9796129 | 0.77 | CYP4F2 (0.36) | — | |
| SCHEMBL25933186 | 0.75 | GLA (0.42) | GPR139TNFADRA1DADRA1AADRA2B | |
| SCHEMBL8265199 | 0.73 | FFAR1 (0.41) | FFAR1GPR139TNFGLACNR1 | |
| SCHEMBL27228864 | 0.72 | GLA (0.42) | GPR139TNFADRA1DADRA1AADRA2B | |
| SCHEMBL17077541 | 0.70 | PDCD1 (0.50) | FFAR1GPR139TNFCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093695-A1 | FACTOR XIIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |