Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16672627 | 0.84 | LMNA (0.45) | LMNAAOC3PSEN1PSEN2APH1B | |
| SCHEMBL28343639 | 0.84 | AOC3 (0.43) | AOC3MAPK1ALDH1A1 | |
| SCHEMBL28343640 | 0.84 | AOC3 (0.43) | AOC3MAPK1ALDH1A1 | |
| SCHEMBL21625878 | 0.83 | LMNA (0.44) | LMNAAOC3ACP3PABPC1APOBEC3A | |
| SCHEMBL765398 | 0.82 | PABPC1 (0.52) | LMNAPABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL20179578 | 0.82 | PABPC1 (0.52) | LMNAPABPC1APOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL9796129 | 0.81 | CYP4F2 (0.36) | PABPC1APOBEC3AAPOBEC3GMAPTRECQL | |
| SCHEMBL28343199 | 0.81 | ACHE (0.45) | LMNAPABPC1APOBEC3AAPOBEC3GMAPT | |
| SCHEMBL28343201 | 0.81 | ACHE (0.45) | LMNAPABPC1APOBEC3AAPOBEC3GMAPT | |
| SCHEMBL20179637 | 0.80 | FFAR1 (0.41) | CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006534-A | Substituted ethers, thioethers and amines for use as lipoxygenase inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-09 | — | — | US | disclosed |