Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24799334 | 0.72 | USP2 (0.44) | USP2HPGDGAANPSR1ALDH1A1 | |
| SCHEMBL20179460 | 0.69 | USP2 (0.43) | USP2HTTGAANPSR1ALDH1A1 | |
| SCHEMBL24798935 | 0.69 | USP2 (0.44) | USP2HPGDGAANPSR1ALDH1A1 | |
| SCHEMBL24804488 | 0.69 | TSHR (0.50) | USP2HPGDHTTGAANPSR1 | |
| SCHEMBL9784530 | 0.69 | USP2 (0.82) | USP2HPGDGAAALDH1A1TSHR | |
| SCHEMBL8269685 | 0.67 | USP2 (0.85) | USP2HPGDGAAALDH1A1TSHR | |
| SCHEMBL1107021 | 0.66 | GAA (0.62) | USP2HPGDHTTGAANPSR1 | |
| SCHEMBL24805790 | 0.66 | MAPT (0.57) | USP2HPGDGAANPSR1ALDH1A1 | |
| SCHEMBL6078444 | 0.66 | LMNA (0.60) | USP2HPGDHTTGAAALDH1A1 | |
| SCHEMBL8269659 | 0.65 | USP2 (0.76) | USP2HPGDGAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093695-A1 | FACTOR XIIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |