SCHEMBL20180020

SCHEMBL20180020

Cc1c(I)c(I)cc2ccccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.45
CYP1A2 P05177 6/20 0.45
TSHR P16473 3/20 0.45
ALDH1A1 P00352 6/20 0.39
HSD17B10 Q99714 5/20 0.39
HIF1A Q16665 2/20 0.39
CYP1B1 Q16678 1/20 0.39
HPGD P15428 3/20 0.38
KDM4E B2RXH2 2/20 0.38
GAA P10253 1/20 0.38
GRIN2D O15399 1/20 0.37
GRIN2A Q12879 1/20 0.37
GRIN2C Q14957 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.36
CYP3A4 P08684 1/20 0.36
MAPK1 P28482 1/20 0.36
CASP1 P29466 1/20 0.36
RAB9A P51151 1/20 0.36
CASP7 P55210 1/20 0.36
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylamine SCHEMBL5612725 0.96 CYP2A6 (0.42) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL24789511 0.83 CYP1A2 (0.50) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL5638671 0.79 ALDH1A1 (0.44) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL29360084 0.76 CYP1A2 (0.56) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL119090 0.76 CYP1A2 (0.56) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL5575751 0.75 CYP1A2 (0.41) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
SCHEMBL21360527 0.75 HSD17B10 (0.42) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
Ammonia Solution, Strong SCHEMBL28178967 0.74 CYP1A2 (0.54) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
Hydrochloric Acid SCHEMBL27879112 0.74 CYP1A2 (0.54) CYP2A6CYP1A2TSHRALDH1A1HSD17B10
Hydrogen Sulfide SCHEMBL27306888 0.74 CYP1A2 (0.54) CYP2A6CYP1A2TSHRALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10400003-B2 Organometallic compound, organic light-emitting device including the same, and diagnostic composition including the organometallic compound SAMSUNG ELECTRONICS CO., LTD. (KR) 2019-09-03 US disclosed
US-20180141969-A1 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND SAMSUNG ELECTRONICS CO., LTD. (KR) 2018-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10400003-B2 Organometallic compound, organic light-emitting device including the same, and diagnostic composition including the organometallic compound ORC3, LEF1, OCIAD1 CYP2A6 1419/4885CYP1A2 428/4885TSHR 3663/4885
US-20180141969-A1 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND ORC3, LEF1, OCIAD1 CYP2A6 1419/4885CYP1A2 428/4885TSHR 3663/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.