Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766040 | 0.74 | ADORA1 (0.43) | ADORA3ADORA1CTSLCTSSCTSK | |
| SCHEMBL21766024 | 0.73 | ADORA1 (0.42) | ADORA3ADORA1CTSLCTSSCTSK | |
| SCHEMBL20180078 | 0.73 | ADORA3 (0.38) | ADORA3ADORA1CTSLCTSSCTSK | |
| SCHEMBL20180099 | 0.71 | CTSL (0.51) | ADORA3YTHDC1ADORA1CTSLCTSS | |
| SCHEMBL20180118 | 0.71 | ADORA3 (0.38) | ADORA3ADORA1CTSLCTSSCTSK | |
| SCHEMBL21766033 | 0.71 | P2RY1 (0.40) | ADORA3ADORA1CTSLCTSSCTSK | |
| SCHEMBL20180119 | 0.71 | NT5E (0.43) | ADORA3YTHDC1ADORA1CTSLADORA2A | |
| SCHEMBL21766008 | 0.66 | ADORA1 (0.41) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL20180325 | 0.66 | ADORA1 (0.41) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL20180117 | 0.65 | ADORA3 (0.35) | ADORA3ADORA1ADORA2AADORA2BHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |