Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263284 | 0.80 | ADORA3 (0.57) | CTSLCTSBADORA3ADORA1ADORA2A | |
| SCHEMBL21766040 | 0.77 | ADORA1 (0.43) | CTSLCTSBADORA3ADORA1ADORA2A | |
| SCHEMBL21766024 | 0.77 | ADORA1 (0.42) | CTSLADORA3ADORA1ADORA2ACTSS | |
| SCHEMBL17929772 | 0.77 | YTHDC1 (0.63) | CTSLCTSBADORA3ADORA1ADORA2A | |
| SCHEMBL20180119 | 0.77 | NT5E (0.43) | CTSLCTSBADORA3ADORA1ADORA2A | |
| SCHEMBL7442349 | 0.75 | ADORA1 (0.64) | ADORA3ADORA1ADORA2AYTHDC1ADORA2B | |
| SCHEMBL22215100 | 0.75 | P2RY1 (0.43) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL17262783 | 0.75 | YTHDC1 (0.61) | CTSLCTSBADORA3ADORA1ADORA2A | |
| SCHEMBL20180078 | 0.75 | ADORA3 (0.38) | CTSLADORA3ADORA1ADORA2ACTSS | |
| SCHEMBL182902 | 0.74 | ADORA1 (0.63) | ADORA3ADORA1ADORA2AYTHDC1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |