Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.37 |
| ▸ | HTR3B | O95264 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180543 | 0.85 | SMN1; SMN2 (0.42) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL21388466 | 0.82 | HRH4 (0.46) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL10126855 | 0.80 | KDM4E (0.61) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL13416764 | 0.80 | CCR4 (0.43) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL20180555 | 0.78 | KDM4E (0.64) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL20180762 | 0.78 | MAPT (0.39) | KDM4EMAPTRAD52HRH4POLB | |
| SCHEMBL25675632 | 0.77 | HRH4 (0.45) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL13416761 | 0.77 | HRH4 (0.46) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL17340291 | 0.76 | SMN1; SMN2 (0.42) | KDM4EMAPTRAD52DRD2DRD3 | |
| SCHEMBL17690602 | 0.76 | MAPT (0.40) | KDM4EMAPTRAD52DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |