Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21388466 | 0.77 | HRH4 (0.46) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL20180554 | 0.76 | KDM4E (0.47) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL13416764 | 0.76 | CCR4 (0.43) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL10126855 | 0.76 | KDM4E (0.61) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL13416761 | 0.73 | HRH4 (0.46) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL25675632 | 0.73 | HRH4 (0.45) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL10126859 | 0.72 | SIRT6 (0.54) | MAPTL3MBTL1SMN1; SMN2POLBBCL2A1 | |
| SCHEMBL17340291 | 0.71 | SMN1; SMN2 (0.42) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL21448015 | 0.71 | DRD2 (0.63) | MAPTKDM4ERAD52HRH4DRD2 | |
| SCHEMBL1938752 | 0.69 | ADRB2 (0.60) | MAPTKDM4ERAD52HRH4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009428-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |