Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.38 |
| ▸ | HTR3B | O95264 | 2/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180504 | 0.83 | NPSR1 (0.53) | MAPTSMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL24722735 | 0.79 | MAPT (0.39) | MAPTSMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL20180496 | 0.79 | ADRA2C (0.48) | MAPTALDH1A1POLBHTTHRH4 | |
| SCHEMBL25925988 | 0.78 | ALDH1A1 (0.42) | MAPTSMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL20180554 | 0.78 | KDM4E (0.47) | MAPTPOLBHTR3AHTR3EHTR3B | |
| SCHEMBL24773959 | 0.78 | HRH4 (0.40) | MAPTSMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL28906234 | 0.77 | HRH4 (0.32) | MAPTSMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL21964914 | 0.76 | HTR1A (0.46) | MAPTSMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL1934165 | 0.75 | MAPT (0.49) | MAPTALDH1A1POLBHTTHTR3A | |
| SCHEMBL14543377 | 0.74 | ALDH1A1 (0.53) | MAPTALDH1A1POLBHTTHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |