Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 18/20 | 0.64 |
| ▸ | USP14 | P54578 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180361 | 0.89 | DGAT2 (0.52) | DGAT2MAPK8 | |
| SCHEMBL20180268 | 0.88 | DGAT2 (0.62) | DGAT2 | |
| SCHEMBL20166203 | 0.86 | DGAT2 (0.66) | DGAT2MAPK8 | |
| SCHEMBL20166496 | 0.80 | DGAT2 (0.70) | DGAT2 | |
| SCHEMBL20166183 | 0.79 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20167169 | 0.78 | DGAT2 (0.75) | DGAT2 | |
| SCHEMBL20180267 | 0.78 | DGAT2 (0.51) | DGAT2 | |
| SCHEMBL20166273 | 0.73 | DGAT2 (0.63) | DGAT2 | |
| SCHEMBL347648 | 0.72 | DGAT2 (0.58) | DGAT2 | |
| SCHEMBL20166313 | 0.71 | DGAT2 (0.65) | DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541376-B1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME LLC (US) | 2023-04-19 | — | — | EP | disclosed |
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-09-12 | — | — | US | disclosed |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-09-12 | — | — | US | disclosed |
| WO-2018093698-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947222-B2 | Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | DGAT2, DGAT1, MOGAT2 | DGAT2 1/4885USP14 3370/4885MAPK8 3689/4885 |
| US-20190276443-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | DGAT2 1/4885USP14 3370/4885MAPK8 3689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.