Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 11/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CENPE | Q02224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180580 | 0.78 | DGAT2 (0.64) | DGAT2 | |
| SCHEMBL20180369 | 0.77 | DGAT2 (0.52) | DGAT2ALDH1A1RORC | |
| SCHEMBL20180640 | 0.76 | DGAT2 (0.57) | DGAT2TP53 | |
| SCHEMBL20180361 | 0.67 | DGAT2 (0.52) | DGAT2 | |
| SCHEMBL15615074 | 0.66 | KDM4E (0.60) | ALDH1A1KMT2A | |
| SCHEMBL20166273 | 0.65 | DGAT2 (0.63) | DGAT2KMT2ARORC | |
| SCHEMBL20526641 | 0.65 | JAK2 (0.48) | ALDH1A1LMNA | |
| SCHEMBL13652592 | 0.64 | ALDH1A1 (0.46) | ALDH1A1KMT2AHSD11B1 | |
| SCHEMBL5896326 | 0.64 | ALDH1A1 (0.46) | ALDH1A1KMT2APTGS2 | |
| SCHEMBL21890268 | 0.64 | KDM4E (0.56) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093698-A1 | INDOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |