Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439240 | 0.93 | CYP1A2 (0.37) | LMNACYP1A2FFAR3CYP2C19 | |
| SCHEMBL5162261 | 0.84 | — | — | |
| SCHEMBL15049000 | 0.83 | FKBP1A (0.34) | MAPTLMNACYP1A2TSHRCYP2C19 | |
| SCHEMBL15048929 | 0.83 | FKBP1A (0.34) | MAPTLMNACYP1A2TSHRCYP2C19 | |
| SCHEMBL15048930 | 0.83 | FKBP1A (0.34) | MAPTLMNACYP1A2TSHRCYP2C19 | |
| SCHEMBL15048999 | 0.83 | FKBP1A (0.34) | MAPTLMNACYP1A2TSHRCYP2C19 | |
| SCHEMBL15821446 | 0.78 | CYP2C19 (0.36) | MAPTCYP2C19FKBP1A | |
| SCHEMBL6142784 | 0.76 | LMNA (0.33) | LMNATSHRCYP2C19 | |
| SCHEMBL7130222 | 0.76 | LMNA (0.33) | LMNATSHRCYP2C19 | |
| SCHEMBL2832691 | 0.76 | LMNA (0.33) | LMNATSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |