Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015686 | 0.85 | HCRTR1 (0.55) | HCRTR1HCRTR2RAB9ANPC1OPRM1 | |
| SCHEMBL2017397 | 0.84 | HCRTR1 (0.57) | HCRTR1HCRTR2RAB9ANPC1OPRM1 | |
| SCHEMBL2015404 | 0.82 | HCRTR1 (0.57) | HCRTR1HCRTR2RAB9ANPC1OPRM1 | |
| SCHEMBL2010539 | 0.82 | HCRTR1 (0.63) | HCRTR1HCRTR2RAB9ANPC1PADI4 | |
| SCHEMBL2014309 | 0.82 | HCRTR1 (0.57) | HCRTR1HCRTR2RAB9ANPC1OPRM1 | |
| SCHEMBL2014229 | 0.82 | HCRTR1 (0.58) | HCRTR1HCRTR2RAB9ANPC1OPRM1 | |
| SCHEMBL2013183 | 0.81 | HCRTR1 (0.61) | HCRTR1HCRTR2RAB9ANPC1HRH3 | |
| SCHEMBL2012310 | 0.80 | HCRTR1 (0.67) | HCRTR1HCRTR2RAB9ANPC1PADI4 | |
| SCHEMBL2013416 | 0.80 | HCRTR1 (0.60) | HCRTR1HCRTR2RAB9ANPC1OPRM1 | |
| SCHEMBL2013001 | 0.80 | HCRTR1 (0.56) | HCRTR1HCRTR2RAB9ANPC1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |