Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 11/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22811354 | 0.73 | APLNR (0.59) | APLNR | |
| SCHEMBL20201181 | 0.72 | APLNR (0.49) | APLNRTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL22811337 | 0.72 | APLNR (0.71) | APLNR | |
| SCHEMBL20181394 | 0.70 | APLNR (0.49) | APLNRTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL20181311 | 0.69 | APLNR (0.53) | APLNRTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL30445549 | 0.65 | TP53 (0.47) | TSHRSMN1; SMN2NPC1TP53L3MBTL1 | |
| SCHEMBL27867743 | 0.64 | TP53 (0.46) | APLNRTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL18482477 | 0.63 | APLNR (0.76) | APLNRTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL1959294 | 0.62 | TP53 (0.43) | APLNRTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL31536793 | 0.61 | GRIN1 (0.39) | TSHRSMN1; SMN2NPC1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093580-A1 | TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |