Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14946922 | 0.76 | CDK9 (0.42) | APLNRNPC1TSHRTP53ALDH1A1 | |
| SCHEMBL20181127 | 0.75 | APLNR (0.51) | APLNRNPC1SMN1; SMN2TSHRTP53 | |
| SCHEMBL20181311 | 0.75 | APLNR (0.53) | APLNRNPC1SMN1; SMN2TSHRTP53 | |
| SCHEMBL27130016 | 0.71 | L3MBTL1 (0.53) | NPC1SMN1; SMN2TP53ALDH1A1RAB9A | |
| SCHEMBL20181280 | 0.70 | APLNR (0.52) | APLNRNPC1SMN1; SMN2TSHRTP53 | |
| SCHEMBL19549092 | 0.68 | ALDH1A1 (0.51) | APLNRNPC1SMN1; SMN2TSHRTP53 | |
| SCHEMBL18482477 | 0.67 | APLNR (0.76) | APLNRNPC1SMN1; SMN2TSHRTP53 | |
| SCHEMBL1959294 | 0.66 | TP53 (0.43) | APLNRNPC1SMN1; SMN2TSHRTP53 | |
| SCHEMBL23202350 | 0.66 | KDM4E (0.42) | NPC1SMN1; SMN2TP53ALDH1A1RAB9A | |
| SCHEMBL19914238 | 0.65 | ALDH1A1 (0.41) | SMN1; SMN2TSHRALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093580-A1 | TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |