Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22810495 | 0.69 | APLNR (0.72) | APLNR | |
| SCHEMBL21328298 | 0.68 | APLNR (1.00) | APLNR | |
| SCHEMBL12578009 | 0.61 | TDP1 (0.67) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL20200907 | 0.61 | APLNR (0.52) | APLNR | |
| SCHEMBL20201183 | 0.60 | APLNR (0.52) | APLNR | |
| SCHEMBL11983826 | 0.59 | TDP1 (0.62) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL21929982 | 0.59 | TDP1 (0.62) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL10064162 | 0.59 | TDP1 (0.62) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL22805586 | 0.56 | MGLL (0.32) | MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL14557181 | 0.55 | ALDH1A1 (0.40) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |