Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 5/20 | 0.34 |
| ▸ | CFTR | P13569 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | SRC | P12931 | 5/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | TEK | Q02763 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | SIK1 | P57059 | 1/20 | 0.32 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.32 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.31 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181916 | 0.87 | CFTR (0.39) | EIF2AK3CFTREGFRSRCKDR | |
| SCHEMBL20182265 | 0.79 | NTRK1 (0.36) | EIF2AK3CFTREGFRKDRFLT3 | |
| SCHEMBL20182274 | 0.79 | EIF2AK3 (0.40) | EIF2AK3EGFRSRCKDRTEK | |
| SCHEMBL20182194 | 0.78 | EIF2AK3 (0.36) | EIF2AK3CFTREGFRSRCKDR | |
| SCHEMBL20182288 | 0.77 | EIF2AK3 (0.39) | EIF2AK3CFTREGFRSRCKDR | |
| SCHEMBL20182224 | 0.77 | EGFR (0.39) | CFTREGFRSRCKDRTEK | |
| SCHEMBL20182271 | 0.76 | CFTR (0.35) | EIF2AK3CFTREGFRSRCKDR | |
| SCHEMBL20182191 | 0.76 | ALK (0.34) | EIF2AK3CFTREGFRSRCKDR | |
| SCHEMBL20182227 | 0.74 | EGFR (0.36) | EIF2AK3EGFRSRCKDRTEK | |
| SCHEMBL20182200 | 0.73 | KDR (0.39) | EIF2AK3SRCKDRTEKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |