Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ADK | P55263 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182248 | 0.89 | LRRK2 (0.34) | — | |
| SCHEMBL20182343 | 0.88 | ADK (0.31) | ADK | |
| SCHEMBL20182234 | 0.79 | EGFR (0.35) | — | |
| SCHEMBL20182195 | 0.77 | NTRK1 (0.33) | — | |
| SCHEMBL20182255 | 0.77 | SRC (0.39) | — | |
| SCHEMBL20182197 | 0.76 | CFTR (0.43) | — | |
| SCHEMBL20182198 | 0.76 | SRC (0.34) | — | |
| SCHEMBL20181916 | 0.74 | CFTR (0.39) | — | |
| SCHEMBL20182194 | 0.74 | EIF2AK3 (0.36) | — | |
| SCHEMBL20182202 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |