Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 8/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | TEK | Q02763 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182288 | 0.85 | EIF2AK3 (0.39) | EIF2AK3KDRRETTEKSRC | |
| SCHEMBL20173329 | 0.82 | EIF2AK3 (0.38) | EIF2AK3TEKSRCLCK | |
| SCHEMBL20182362 | 0.81 | CFTR (0.40) | KDRRETTEKSRCLCK | |
| SCHEMBL20182227 | 0.81 | EGFR (0.36) | EIF2AK3KDRRETTEKSRC | |
| SCHEMBL20181916 | 0.80 | CFTR (0.39) | EIF2AK3KDRTEKSRCLCK | |
| SCHEMBL20182194 | 0.80 | EIF2AK3 (0.36) | EIF2AK3KDRRETTEKSRC | |
| SCHEMBL20182228 | 0.79 | KDR (0.45) | KDRTEKSRCLCKEGFR | |
| SCHEMBL20181906 | 0.79 | EIF2AK3 (0.34) | EIF2AK3KDRRETTEKSRC | |
| SCHEMBL20182283 | 0.79 | NTRK1 (0.36) | KDRRETTEKSRCLCK | |
| SCHEMBL20182241 | 0.79 | KDR (0.46) | EIF2AK3KDRTEKSRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |