Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21376714 | 0.87 | PRMT1 (0.36) | TP53SMN1; SMN2PRMT1ALDH1A1MAPK1 | |
| SCHEMBL22902138 | 0.84 | PRMT1 (0.34) | TP53SMN1; SMN2PRMT1ALDH1A1MAPK1 | |
| SCHEMBL21538336 | 0.80 | PRMT1 (0.44) | TP53SMN1; SMN2PRMT1ALDH1A1MAPK1 | |
| SCHEMBL21892022 | 0.79 | PRMT1 (0.34) | PRMT1ALDH1A1POLB | |
| SCHEMBL17190557 | 0.79 | STAT3 (0.41) | SMN1; SMN2ALDH1A1MAPK1POLBCA2 | |
| SCHEMBL17190561 | 0.73 | FAAH (0.38) | ALDH1A1POLB | |
| SCHEMBL21846596 | 0.71 | PRMT1 (0.40) | PRMT1ALDH1A1MAPK1POLBRXFP1 | |
| SCHEMBL21846597 | 0.68 | PPARA (0.34) | ALDH1A1POLB | |
| SCHEMBL21846601 | 0.65 | PRMT1 (0.33) | PRMT1ALDH1A1 | |
| SCHEMBL12733507 | 0.64 | CYP3A4 (0.45) | TP53SMN1; SMN2ALDH1A1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-10626666-B2 | Device for regulating the passage of light | MERCK PATENT GMBH (DE) | 2020-04-21 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |