Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989728 | 0.90 | POLB (0.39) | POLBGRIN1GRIN2BALOX5APFEN1 | |
| SCHEMBL25885629 | 0.90 | POLB (0.39) | POLBGRIN1GRIN2BALOX5APFEN1 | |
| SCHEMBL14684583 | 0.90 | POLB (0.48) | POLBDDR1ALOX5APFEN1 | |
| SCHEMBL29360277 | 0.90 | POLB (0.48) | POLBDDR1ALOX5APFEN1 | |
| SCHEMBL25888089 | 0.89 | POLB (0.38) | POLBGRIN1GRIN2BMAPK10PTGS2 | |
| SCHEMBL20182758 | 0.89 | POLB (0.44) | POLBGRIN1GRIN2BDDR1ALOX5AP | |
| SCHEMBL20182714 | 0.89 | POLB (0.40) | POLBGRIN1GRIN2BPTGS2 | |
| SCHEMBL17696196 | 0.88 | PTGS2 (0.36) | GRIN1GRIN2BJAK2JAK1TYK2 | |
| SCHEMBL18866344 | 0.87 | POLB (0.42) | POLBGRIN1GRIN2BDDR1PTGS2 | |
| SCHEMBL15868301 | 0.87 | POLB (0.46) | POLBDDR1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018091389-A1 | PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-05-24 | — | — | WO | disclosed |