Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | AIMP2 | Q13155 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182824 | 0.86 | LTB4R (0.56) | PSMB5MAPTMEN1KMT2AHDAC8 | |
| SCHEMBL20182939 | 0.82 | PSMB5 (0.50) | PSMB5MAPTMEN1KMT2AHDAC8 | |
| SCHEMBL25626161 | 0.81 | PSMB5 (0.49) | PSMB5MAPTMEN1KMT2AHDAC8 | |
| SCHEMBL20182869 | 0.77 | AIMP2 (0.56) | PSMB5MAPTLTB4RLTB4R2AIMP2 | |
| SCHEMBL20182940 | 0.75 | GRM7 (0.64) | PSMB5MAPTLTB4RLTB4R2AIMP2 | |
| SCHEMBL25625908 | 0.73 | P2RX7 (0.48) | PSMB5AIMP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20182785 | 0.73 | AIMP2 (0.52) | PSMB5AIMP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20182838 | 0.72 | AIMP2 (0.51) | PSMB5AIMP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL696876 | 0.71 | LTB4R (0.47) | PSMB5LTB4RLTB4R2ALDH1A1POLB | |
| SCHEMBL697337 | 0.71 | LTB4R (0.47) | PSMB5LTB4RLTB4R2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |