Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182869 | 0.85 | AIMP2 (0.56) | GRM7AIMP2LTB4RLTB4R2PSMB5 | |
| SCHEMBL20182824 | 0.85 | LTB4R (0.56) | GRM7AIMP2LTB4RLTB4R2PSMB5 | |
| SCHEMBL20182938 | 0.78 | GRM7 (1.00) | GRM7DRD2DRD3LTB4RLTB4R2 | |
| SCHEMBL21542297 | 0.78 | GRM7 (1.00) | GRM7DRD2DRD3LTB4RLTB4R2 | |
| SCHEMBL21542299 | 0.78 | GRM7 (1.00) | GRM7DRD2DRD3LTB4RLTB4R2 | |
| SCHEMBL20182774 | 0.75 | PSMB5 (0.52) | AIMP2LTB4RLTB4R2PSMB5RAB9A | |
| SCHEMBL20182785 | 0.74 | AIMP2 (0.52) | GRM7AIMP2PSMB5SIGMAR1RAB9A | |
| SCHEMBL20182838 | 0.74 | AIMP2 (0.51) | GRM7AIMP2PSMB5SIGMAR1RAB9A | |
| SCHEMBL20182939 | 0.73 | PSMB5 (0.50) | AIMP2LTB4RLTB4R2PSMB5ALDH1A1 | |
| SCHEMBL12066948 | 0.73 | GRM7 (0.54) | GRM7DRD2DRD3LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541812-B1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICALS CO (JP) | 2023-06-14 | — | — | EP | disclosed |
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |