Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953669 | 0.79 | MEN1 (0.42) | MEN1KMT2AKCNH2MAPTALDH1A1 | |
| SCHEMBL20113096 | 0.77 | GRM7 (0.55) | MEN1KMT2ACHRM4KCNH2MAPT | |
| SCHEMBL20166097 | 0.73 | GRM7 (0.39) | MEN1KMT2ACHRM4KCNH2MAPT | |
| SCHEMBL11275259 | 0.69 | KDM4E (0.42) | MEN1KMT2AKCNH2ALDH1A1ACE | |
| SCHEMBL1998760 | 0.68 | HDAC4 (0.44) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL19953701 | 0.67 | ACE (0.47) | GRM7ACENOTUM | |
| SCHEMBL19960826 | 0.67 | ACE (0.47) | GRM7ACENOTUM | |
| SCHEMBL14879169 | 0.67 | PRCP (0.51) | KMT2AALDH1A1ACENOTUMKDM4E | |
| SCHEMBL5897623 | 0.66 | MEN1 (0.48) | MEN1KMT2AMAPTALDH1A1NOTUM | |
| SCHEMBL7344344 | 0.66 | ACE (0.50) | SIGMAR1MEN1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |