SCHEMBL2018336

SCHEMBL2018336

CCOC(=O)c1cnc2c(OC)cccc2c1NCc1ccc(OC)cc1

nearest known ligand 0.76

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.76
SMN1; SMN2 Q16637 4/20 0.76
GAA P10253 3/20 0.64
ALDH1A1 P00352 8/20 0.62
MAPT P10636 8/20 0.62
LMNA P02545 6/20 0.62
HPGD P15428 3/20 0.62
TDP1 Q9NUW8 1/20 0.62
HTT P42858 1/20 0.60
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
NPSR1 Q6W5P4 2/20 0.59
RAB9A P51151 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
HSD17B10 Q99714 2/20 0.55
MAPK1 P28482 1/20 0.55
TSHR P16473 1/20 0.55
TP53 P04637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2017818 0.92 KDM4E (0.82) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL15170185 0.89 GAA (0.63) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL5672464 0.89 GAA (0.63) KDM4ESMN1; SMN2GAAALDH1A1MAPT
Phosphoric Acid SCHEMBL11249952 0.88 KDM4E (0.76) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL2514745 0.88 KDM4E (0.58) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL13692674 0.86 KDM4E (1.00) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL2016779 0.86 KDM4E (0.73) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL11248284 0.86 KDM4E (0.72) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL2022046 0.84 KDM4E (0.70) KDM4ESMN1; SMN2GAAALDH1A1MAPT
SCHEMBL2515206 0.84 MAPT (0.62) KDM4ESMN1; SMN2GAAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140128481-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2014-05-08 US claimed
EP-2552207-A1 SWEET FLAVOR MODIFIER Senomyx, Inc. (US) 2013-02-06 EP claimed
WO-2011123693-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2011-10-06 WO claimed
US-20110245353-A1 SWEET FLAVOR MODIFIER SENOMYS, INC. (US) 2011-10-06 US claimed
US-10568888-B2 Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors VTV THERAPEUTICS LLC (US) 2020-02-25 US disclosed
US-20190336506-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS HIGH POINT PHARMACEUTICALS, LLC 2019-11-07 US disclosed
US-10391097-B2 Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors VTV THERAPEUTICS LLC (US) 2019-08-27 US disclosed
EP-2552207-B1 SWEET FLAVOR MODIFIER FIRMENICH INCORPORATED (US) 2019-08-21 EP disclosed
US-20180360839-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS TRANSTECH PHARMA, INC. 2018-12-20 US disclosed
US-10085990-B2 Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors VTV THERAPEUTICS LLC (US) 2018-10-02 US disclosed
US-20180071297-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS VTV THERAPEUTICS LLC 2018-03-15 US disclosed
US-9902737-B2 Sweet flavor modifier SENOMYX, INC. (US) 2018-02-27 US disclosed
US-20110160234-A1 Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors HIGH POINT PHARMACEUTICALS, LLC (US) 2011-06-30 US disclosed
US-7964608-B2 Tricyclic compounds as modulators of TNF-α synthesis HIGH POINT PHARMACEUTICALS, LLC (US) 2011-06-21 US disclosed
EP-2244574-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF- SYNTHESIS AND AS PDE4 INHIBITORS High Point Pharmaceuticals, LLC (US) 2010-11-03 EP disclosed
US-20100190808-A1 Tricyclic Compounds As Modulators of TNF-alpha Synthesis HIGH POINT PHARMACEUTICALS, LLC. (US) 2010-07-29 US disclosed
WO-2009094528-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS HIGH POINT PHARMACEUTICALS, LLC (US) 2009-07-30 WO disclosed
US-6410529-B1 DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2002-06-25 US disclosed
EP-1003737-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-05-31 EP disclosed
WO-1999009024-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190336506-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS PDE4A, PDE4B, TNF KDM4E 1478/4885SMN1; SMN2 4826/4885GAA 288/4885
US-20180360839-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4C KDM4E 1135/4885SMN1; SMN2 4458/4885GAA 337/4885
US-20100190808-A1 Tricyclic Compounds As Modulators of TNF-alpha Synthesis TNF, PDE4A, PDE4B KDM4E 1810/4885SMN1; SMN2 4631/4885GAA 1212/4885
US-10568888-B2 Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors PDE4A, PDE4B, TNF KDM4E 1478/4885SMN1; SMN2 4826/4885GAA 288/4885
US-20110160234-A1 Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors PDE4A, PDE4B, TNF KDM4E 1235/4885SMN1; SMN2 4537/4885GAA 1029/4885
US-20110245353-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 KDM4E 1475/4885SMN1; SMN2 2246/4885GAA 123/4885
US-20180071297-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4C KDM4E 1135/4885SMN1; SMN2 4458/4885GAA 337/4885
US-20140128481-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 KDM4E 1475/4885SMN1; SMN2 2246/4885GAA 123/4885
US-10085990-B2 Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors PDE4A, TNF, PDE4B KDM4E 1009/4885SMN1; SMN2 4506/4885GAA 345/4885
US-10391097-B2 Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors PDE4A, PDE4B, PDE4C KDM4E 1135/4885SMN1; SMN2 4458/4885GAA 337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.