SCHEMBL20183493

SCHEMBL20183493

CCN(CC)c1ccc(C(=O)N(C)c2ccc3c(c2)c(C2CC2)cc(=O)n3CC)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.37
ALDH1A1 P00352 5/20 0.37
MAPK1 P28482 2/20 0.37
RAB9A P51151 2/20 0.37
LMNA P02545 2/20 0.35
HTT P42858 1/20 0.35
NPY5R Q15761 1/20 0.35
KDM4E B2RXH2 2/20 0.34
EGFR P00533 1/20 0.34
ERBB2 P04626 1/20 0.34
HPGD P15428 2/20 0.34
GFER P55789 2/20 0.34
NPC1 O15118 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
RORC P51449 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
USP2 O75604 1/20 0.33
CYP2C19 P33261 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20183805 0.92 ALDH1A1 (0.37) MAPTALDH1A1RAB9AHTTNPY5R
SCHEMBL20183518 0.91 BRD4 (0.39) MAPTALDH1A1MAPK1RAB9ANPY5R
SCHEMBL20183680 0.91 MCHR1 (0.39) ALDH1A1RAB9AHTTNPY5RKDM4E
SCHEMBL20183496 0.90 ALDH1A1 (0.36) MAPTALDH1A1RAB9AHTTNPY5R
SCHEMBL20183620 0.90 ITK (0.38) MAPTALDH1A1HTTNPY5RKDM4E
SCHEMBL20183710 0.90 SMN1; SMN2 (0.37) MAPTALDH1A1RAB9ANPY5RKDM4E
SCHEMBL20183851 0.90 ALDH1A1 (0.41) MAPTALDH1A1HTTNPY5RKDM4E
SCHEMBL20183767 0.89 HTT (0.43) MAPTALDH1A1LMNAHTTNPY5R
SCHEMBL20183564 0.88 ALDH1A1 (0.35) MAPTALDH1A1RAB9ALMNAHTT
SCHEMBL20183717 0.88 HPGD (0.36) MAPTALDH1A1RAB9ALMNANPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10987349-B2 Antitumor agent and bromodomain inhibitor FUJIFILM CORPORATION (JP) 2021-04-27 US disclosed
US-10987349-B2 Antitumor agent and bromodomain inhibitor FUJIFILM CORPORATION (JP) 2021-04-27 US disclosed
EP-3563851-B1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM CORP (JP) 2021-04-21 EP disclosed
EP-3327004-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORP (JP) 2020-11-04 EP disclosed
US-10696637-B2 Nitrogen-containing heterocyclic compound FUJIFILM CORPORATION (JP) 2020-06-30 US disclosed
US-10696637-B2 Nitrogen-containing heterocyclic compound FUJIFILM CORPORATION (JP) 2020-06-30 US disclosed
US-10633343-B2 2020-04-28 US disclosed
US-10633343-B2 2020-04-28 US disclosed
EP-3563851-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM Corporation (JP) 2019-11-06 EP disclosed
US-20190314360-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM CORPORATION (JP) 2019-10-17 US disclosed
US-20190314360-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM CORPORATION (JP) 2019-10-17 US disclosed
US-20190077761-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORPORATION (JP) 2019-03-14 US disclosed
US-20190077761-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORPORATION (JP) 2019-03-14 US disclosed
EP-3327004-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND Fujifilm Corporation (JP) 2018-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10987349-B2 Antitumor agent and bromodomain inhibitor BRD4, BRD1, BRD3 MAPT 3928/4885ALDH1A1 3243/4885MAPK1 1104/4885
US-10696637-B2 Nitrogen-containing heterocyclic compound CXCL10, CCL5, CXCR3 MAPT 4325/4885ALDH1A1 3095/4885MAPK1 994/4885
US-20190314360-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR BRD4, BRD1, BRD3 MAPT 3928/4885ALDH1A1 3243/4885MAPK1 1104/4885
US-20190077761-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CXCL10, CCL5, CXCR3 MAPT 4325/4885ALDH1A1 3095/4885MAPK1 994/4885
US-10633343-B2 CXCL10, CCL5, CXCR3 MAPT 4406/4885ALDH1A1 2674/4885MAPK1 1360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.