Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL1968070 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL9762549 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL1968077 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL5875130 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL3669578 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL9761371 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL9762551 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL1968079 | 0.97 | TSHR (0.53) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL27312490 | 0.85 | TSHR (0.60) | TSHRNAPRTTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL27512927 | 0.85 | TSHR (0.60) | TSHRNAPRTTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327007-B1 | ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR | SHENZHEN ZHENXING MEDICAL TECH CO LTD (CN) | 2020-06-03 | — | — | EP | disclosed |
| US-10561667-B2 | Orbit azine-fumarate, hydrate, crystal form and preparation method therefor | SHENZHEN ZHENXING MEDICAL TECHNOLOGY CO., LTD. (CN) | 2020-02-18 | — | — | US | disclosed |
| US-20180214456-A1 | ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR | SHENZHEN ZHENXING MEDICAL TECHNOLOGY CO., LTD. (CN) | 2018-08-02 | — | — | US | disclosed |
| EP-3327007-A1 | ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR | Shenzhen Institute Of Xiangya Biomedicine (CN) | 2018-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180214456-A1 | ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR | FH, CYP4F11, CYP2F1 | SLC6A2 4101/4885MEN1 596/4885KMT2A 3439/4885 |
| US-10561667-B2 | Orbit azine-fumarate, hydrate, crystal form and preparation method therefor | FH, CYP4F11, CYP4F8 | SLC6A2 4631/4885MEN1 428/4885KMT2A 3339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.