Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184602 | 0.91 | JAK3 (0.52) | JAK3JAK2 | |
| SCHEMBL20184526 | 0.90 | JAK3 (0.51) | JAK3JAK2MAOB | |
| SCHEMBL20184588 | 0.89 | MMP2 (0.52) | JAK3JAK2MMP2MMP1MMP9 | |
| SCHEMBL20184521 | 0.88 | JAK3 (0.59) | JAK3JAK2AURKAJAK1 | |
| SCHEMBL20184508 | 0.88 | JAK3 (0.59) | JAK3JAK2AURKAJAK1 | |
| SCHEMBL20184418 | 0.87 | JAK3 (0.64) | JAK3JAK2SIRT2SIRT1SIRT3 | |
| SCHEMBL20184370 | 0.87 | MMP1 (0.50) | JAK3JAK2MMP2MMP1MMP9 | |
| SCHEMBL20184704 | 0.87 | JAK3 (0.59) | JAK3JAK2AURKAJAK1 | |
| SCHEMBL20184539 | 0.87 | JAK3 (0.51) | JAK3JAK2AURKAJAK1 | |
| SCHEMBL20184530 | 0.87 | JAK3 (0.49) | JAK3JAK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |