Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | JAK3 | P52333 | 7/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | RXRB | P28702 | 2/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184403 | 0.87 | DHODH (0.42) | HSP90AB1JAK2JAK3RXRARXRB | |
| SCHEMBL20184516 | 0.87 | JAK3 (0.52) | HSP90AB1JAK2JAK3 | |
| SCHEMBL20184389 | 0.87 | JAK3 (0.40) | HSP90AB1JAK2JAK3CAMKK2SGK1 | |
| SCHEMBL20184525 | 0.85 | JAK2 (0.49) | JAK2JAK3CAMKK2SGK1 | |
| SCHEMBL20184489 | 0.83 | JAK2 (0.51) | JAK2JAK3CAMKK2SGK1 | |
| SCHEMBL20184390 | 0.81 | JAK3 (0.45) | JAK3 | |
| SCHEMBL20184337 | 0.81 | JAK2 (0.43) | HSP90AB1JAK2JAK3 | |
| SCHEMBL20184325 | 0.79 | JAK3 (0.59) | HSP90AB1JAK2JAK3 | |
| SCHEMBL20184672 | 0.79 | JAK2 (0.54) | JAK2JAK3CAMKK2SGK1 | |
| SCHEMBL20184551 | 0.79 | JAK3 (0.53) | JAK2JAK3RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |