Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 6/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184405 | 0.87 | HSP90AB1 (0.45) | JAK3JAK2HSP90AB1 | |
| SCHEMBL20184403 | 0.86 | DHODH (0.42) | JAK3JAK2HSP90AB1DHODH | |
| SCHEMBL20184389 | 0.86 | JAK3 (0.40) | JAK3JAK2HSP90AB1CHUK | |
| SCHEMBL20184670 | 0.85 | HSP90AB1 (0.42) | JAK3JAK2HSP90AB1CHUK | |
| SCHEMBL20184525 | 0.84 | JAK2 (0.49) | JAK3JAK2CHUK | |
| SCHEMBL20184489 | 0.82 | JAK2 (0.51) | JAK3JAK2DHODH | |
| SCHEMBL20184555 | 0.81 | HSP90AB1 (0.43) | JAK3JAK2HSP90AB1CHUKDHODH | |
| SCHEMBL20184360 | 0.80 | JAK3 (0.60) | JAK3HSP90AB1 | |
| SCHEMBL20184599 | 0.80 | JAK3 (0.53) | JAK3JAK2HSP90AB1CHUKDHODH | |
| SCHEMBL20184528 | 0.79 | JAK3 (0.41) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |