Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 6/20 | 0.54 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 4/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184489 | 0.88 | JAK2 (0.51) | JAK2JAK3DHODHSGK1CAMKK2 | |
| SCHEMBL20184525 | 0.88 | JAK2 (0.49) | JAK2JAK3SGK1CAMKK2 | |
| SCHEMBL20184551 | 0.84 | JAK3 (0.53) | JAK2JAK3DHODH | |
| SCHEMBL20184548 | 0.84 | JAK3 (0.53) | JAK2JAK3DHODHSGK1CAMKK2 | |
| SCHEMBL20184518 | 0.84 | PRKAB2 (0.48) | JAK2JAK3DHODHKMT2A | |
| SCHEMBL20184527 | 0.83 | JAK2 (0.49) | JAK2JAK3DHODHSGK1CAMKK2 | |
| SCHEMBL20184337 | 0.83 | JAK2 (0.43) | JAK2JAK3RAB9A | |
| SCHEMBL20184581 | 0.83 | JAK3 (0.43) | JAK2JAK3 | |
| SCHEMBL20184478 | 0.83 | JAK2 (0.53) | JAK2JAK3RAB9ADHODH | |
| SCHEMBL20184673 | 0.83 | JAK2 (0.53) | JAK2JAK3RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |